BDB558318
CD282 Mouse anti-Human, Alexa Fluor 488, Clone: 11G7, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB558318-Each-of-1 | In Stock | ₹ 35,422.00 |
BDB558318 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 35,422.00
GST (18%): ₹ 6,375.96
Total Price: ₹ 41,797.96
Antigen
CD282
Classification
Monoclonal
Conjugate
Alexa Fluor 488
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Human TLR2-transfected cell line
Quantity
100 Tests
Research Discipline
Immunology
Target Species
Human
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
11G7
Description
TLR2
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- The monoclonal antibody 11G7 reacts with human CD282, which is also known as Toll-like receptor 2 (TLR2)
- It is primarily expressed by peripheral blood monocytes
- Toll-like receptors (TLRs) play a critical role in anti-microbial resistance
- Moreover, TLRs have been shown to activate a number of signal transduction pathways which lead to the induction of genes involved in host defense
- TLRs are type-1 transmembrane receptors characterized by the presence of extracellular leucine-rich repeat and intracellular Toll/IL-1 receptor domains
- At least 12 mammalian TLRs have been identified, each recognizing a distinct bacterial or viral pathogen-associated molecular pattern, termed PAMP
- Peptidoglycan from Gram-positive bacteria, lipoproteins and lipopeptides from several bacteria, glycophosphatidylinositol, lipoarabinomannan, porins, and zymosan from yeast have been reported to be the ligands for TLR2
- It has been reported that mAb 11G7 inhibits the production of inflammatory cytokines via certain TLR2 ligands including TLR2/TLR1 ligands, lipoarabinomannan and PAM3CSK4
- However, 11G7 antibody does not inhibit the production of inflammatory cytokines with zymosan, a TLR2/TLR6 ligand
- Please note that this application has not been tested at BD Biosciences Pharmingen.