BDB558485
CD272 Mouse anti-Human, PE, Clone: J168-540.90.22, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB558485-Each-of-1 | In Stock | ₹ 50,596.50 |
BDB558485 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,596.50
GST (18%): ₹ 9,107.37
Total Price: ₹ 59,703.87
Antigen
CD272
Classification
Monoclonal
Concentration
0.2mg/mL
Description
BTLA1; B- and T-lymphocyte-associated protein
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
J168-540.90.22
Conjugate
PE
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Human BTLA Recombinant Protein
Quantity
0.1 mg
Research Discipline
Cell Biology
Target Species
Human
Isotype
IgG1 κ
Related Products
Description
- The J168-540 monoclonal antibody specifically binds to human CD272, also known as BTLA (B and T lymphocyte attenuator), an inhibitory receptor expressed in bone marrow and thymus on developing B and T cells
- In the periphery, BTLA is expressed by B cells, T cells, bone marrow-derived dendritic cells, and macrophages
- After T cell activation, BTLA appears to be expressed at higher levels on Th1 cell populations than in Th2 cell populations
- Upon binding the herpesvirus entry mediator (HVEM/LIGHT-R/CD270), CD272 undergoes tyrosine phosphorylation and inhibits T cell proliferation in a BTLA-dependent manner
- CD272 has structural similarities to two other lymphocyte inhibitory receptors, CTLA-4 and PD-1 and is a member of the CD28-like family of coreceptors
- Based on these observations, CD272 is considered to be a negative regulator of lymphocyte activation and/or function.