BDB558701
CD45.1 Mouse anti-Mouse, APC, Clone: A20, BD
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB558701-Each-of-1 | In Stock | ₹ 32,040.00 |
BDB558701 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 32,040.00
GST (18%): ₹ 5,767.20
Total Price: ₹ 37,807.20
Antigen
CD45.1
Classification
Monoclonal
Concentration
0.2mg/mL
Description
Ly-5; Lyt4; CD45R; LCA; Ptprc; Protein tyrosine phosphatase receptor type C
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
A20
Conjugate
APC
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
SJL mouse thymocytes and splenocytes
Quantity
0.1 mg
Research Discipline
Immunology
Target Species
Mouse
Isotype
IgG2a κ
Related Products
Description
- The A20 monoclonal antibody specifically binds to CD45 (Leukocyte Common Antigen) on all leukocytes of mouse strains expressing the CD45.1 alloantigen (eg, RIII, SJL/J, STS/A, DA)
- This alloantigen was originally named Ly-5.2, and this was the designation at the time that the antibody was characterized
- The designation was later changed from Ly-5.2 to Ly-5.1 to conform with the convention that the .2 alloantigen designations be assigned to the C57BL/6 strain
- mAb A20 has been reported not to react with leukocytes of most other mouse strains, which express the CD45.2 alloantigen
- CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and C,respectively), plus differing levels of glycosylation
- The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific
- The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction
- The A20 antibody has been reported to inhibit some responses of B cells, from mice expressing the CD45.1 alloantigen, to antigens and LPS.