BDB562499
CD95 Hamster anti-Mouse, PE-CF594, Clone: Jo2, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB562499-Each-of-1 | In Stock | ₹ 36,490.00 |
BDB562499 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 36,490.00
GST (18%): ₹ 6,568.20
Total Price: ₹ 43,058.20
Antigen
CD95
Classification
Monoclonal
Concentration
0.2mg/mL
Description
Apo-1; Apt1; Fas; FASLG receptor; lpr; TNFR6; Tnfrsf6; TNR6
Host Species
Hamster
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Mouse
Isotype
IgG2
Applications
Flow Cytometry
Clone
Jo2
Conjugate
PE-CF594
Formulation
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen
WR19L mouse lymphoma cells transformed with recombinant mouse Fas
Quantity
0.1 mg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- Fas antigen, CD95, is a 45kDa cell-surface protein which can mediate apoptosis
- It belongs to the TNF (tumor necrosis factor)/NGF receptor family
- Expression of Fas has been described in the thymus, liver, heart, lung and ovary
- Fas plays an important role in the apoptotic process that takes place during development
- Monoclonal antibodies recognizing Fas such as Jo2 have cytolytic activity on cells expressing Fas
- The cell death stimulated by Fas antibodies is characteristic of apoptosis and suggests that the lethal effects are a result of interaction of antibody with a functional Fas antigen as opposed to complement-mediated lysis
- The Jo2 antibody recognizes mouse Fas
- The Jo2 antibody shows cytolytic activity against cell lines expressing mouse Fas by inducing apoptosis
- Intraperitoneal injections of Jo2 mAb have been shown to kill mice and induce apoptotic hepatocyte death
- Jo2 mAb has been reported to immunoprecipitate mouse Fas as a 45kDa band from W4 cells
- W4 cells are WR19L mouse lymphoma cells transformed with mouse Fas
- The difference between the observed MW of Fas and that deduced from its amino acid sequence (Mr 34,971) may be due to glycosylation
- Host Species: Hamster Clone: Jo2 Isotype: IgG2, λ 2 Species Reactivity: Mouse Immunogen: WR19L mouse lymphoma cells transformed with recombinant mouse Fas Flow Cytometry