CD271 Mouse anti-Human, Brilliant Violet 421, Clone: C40-1457, BD

Description

• The C40-1457 monoclonal antibody specifically binds to CD271, the nerve growth factor receptor (NGFR)
• CD271 is a transmembrane 75 kDa protein that has been found localized to neuronal axons, Schwann cells, and perineural cells of peripheral nerves
• It is also expressed by cells in some epithelial, mesenchymal and lymphoid tissues
• NGFR is the receptor for nerve growth factor (NGF), a polypeptide that is essential for normal development of the nervous system
• NGF promotes survival and differentiation of sympathetic and sensory neurons during embryological development of peripheral neurons
• NGF binds to two distinctive surface receptors expressed by target cells, the p140-TrkA (NTRK1) and the p75 NGFR
• High affinity binding of NGF requires that both receptor molecules be expressed
• NGFR has been found on human and rat lymphocytes
• A subset of lymphoid cells in the spleen, lymph nodes, and follicular dentritic cells in germinal centers of reactive lymph nodes were found to express CD271
• It has been reported that NGFR interaction with its ligand, NGF, may play a role in immunoregulation
• NGF may function as a B-cell growth factor
• The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon™ Brilliant Violet™ family of dyes
• With an Ex Max of 407-nm and Em Max at 421-nm, BD Horizon™ BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50-nm filter)
• BD Horizon™ BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue™ conjugates.