BDB562798
CD140A Mouse anti-Human, Alexa Fluor 647, Clone: alphaR1, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB562798-Each-of-1 | In Stock | ₹ 20,826.00 |
BDB562798 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 20,826.00
GST (18%): ₹ 3,748.68
Total Price: ₹ 24,574.68
Antigen
CD140a
Classification
Monoclonal
Conjugate
Alexa Fluor 647
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Human PDGFRα Transfected Cell Line
Quantity
50 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
alphaR1
Description
PDGF Receptor α; PDGFRA; PDGFRα; PDGF-R-alpha; PDGFR2; PGFRA; RHEPDGFRA
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG2a κ
Related Products
Description
- The αR1 monoclonal antibody specifically binds to the human platelet derived growth factor (PDGF) receptor α (PDGFRα), also known as CD140a
- CD140a is a 170 kDa single transmembrane glycoprotein expressed on fibroblasts, smooth muscle cells, glial cells and chondrocytes
- PDGF receptors α and β are single glycoproteins with intracellular tyrosine kinase domains
- They are structurally similar to the M-CSF receptor and CD117 (c-kit)
- Their ligand, PDGF, is a mitogen for connective tissue cells and glial cells
- PDGF plays a role in wound healing and it also acts as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes and neutrophils
- Functional PDGF is secreted in disulfide linked, homodimeric or heterodimeric forms comprised of A or B chains (PDGFAA, PDGF-BB or PDGF-AB)
- Binding of divalent PDGF induces receptor dimerization with three possible forms: αα, αβ, ββ
- The PDGFRα subunit binds both PDGF A and B chains, whereas the PDGFRβ subunit binds only PDGF B chains
- Although both receptor subunits can stimulate mitogenic responses, only the β subunit can induce chemotaxis
- The αR1 antibody is specific for PDGFRα and does not crossreact with PDGFR β
- It immunoprecipitates human, monkey, rabbit, pig, dog and cat PDGFR α
- It does not recognize hamster, rat or mouse PDGFR α .