BDB562937
CD183 Hamster anti-Mouse, Brilliant Violet 421, Clone: CXCR3-173, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB562937-Each-of-1 | In Stock | ₹ 26,166.00 |
BDB562937 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 26,166.00
GST (18%): ₹ 4,709.88
Total Price: ₹ 30,875.88
Antigen
CD183
Classification
Monoclonal
Concentration
0.2mg/mL
Description
CXCR3; Cxcr3; Cd183; Cmkar3; C-X-C chemokine receptor type 3
Host Species
Hamster
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Mouse
Isotype
IgG1
Applications
Flow Cytometry
Clone
CXCR3-173
Conjugate
Brilliant Violet 421
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Mouse CXCR3 peptide (amino acids 1–37)
Quantity
50 μg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Related Products
Description
- The CXCR3-173 monoclonal antibody specifically binds to mouse CD183, also known as CXCR3
- CD183 is a seven transmembrane spanning, G protein-coupled chemokine receptor for CXC chemokines including CXCL9 (Mig), CXCL10 (IP-10) and CXCL11 (I-TAC)
- These chemokines are induced by inflammatory cytokines including IFN- γ, IFN- α / β , and TNF
- CXCR3 is primarily expressed on activated/memory CD4+ and CD8+ T lymphocytes, Foxp+ regulatory T cells, natural killer T (NKT) cells and mature NK cells
- Binding of chemokines to CXCR3 induces integrin activation, cytoskeletal changes, and chemotactic migration of activated lymphocytes
- CD183 has been reported to play important roles in T cell recruitment and immune responses in a number of inflammatory and autoimmune diseases
- The CXCR3-173 antibody reportedly inhibited in vitro chemotactic responses to CXCL10 or CXCL11 significantly but not to CXCL9
- When administered systemically to mouse hosts, the CXCR3-173 antibody reportedly prolonged cardiac and pancreatic islet cell allograft survival
- In the presence of CXCR3 ligands, especially, CXCL10 and CXCL11, staining with the antibody can be significantly blocked.