BDB563487
Foxp3 Rat anti-Mouse, Alexa Fluor 488, Clone: R16-715, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB563487-Each-of-1 | In Stock | ₹ 25,765.50 |
BDB563487 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,765.50
GST (18%): ₹ 4,637.79
Total Price: ₹ 30,403.29
Antigen
Foxp3
Classification
Monoclonal
Concentration
0.2mg/mL
Description
Forkhead box P3; IPEX; Forkhead box protein P3; JM2; Scurfin; Scurfy; Sf
Host Species
Rat
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Mouse
Isotype
IgG2a κ
Applications
Flow Cytometry
Clone
R16-715
Conjugate
Alexa Fluor 488
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Recombinant Protein
Quantity
50 μg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- Description The R16-715 monoclonal antibody specifically binds to mouse Foxp3
- Foxp3 is a 50-55 kDa protein also known as Forkhead box P3, JM2, IPEX, Scurfin, andSf
- It is a member of the forkhead or winged helix family of transcription factors and is specifically expressed by T regulatory (Treg) cells
- Foxp3 is a key regulatory protein for Treg cell development and function
- Ectopic expression of Foxp3 in conventional T cells is sufficient to induce suppressive activity, repress the production of cytokines such as IL2 and IFN-γ, and upregulate Treg cell-associated molecules such as CD25, CTLA4 and GITR
- It has been found that the mutation of Foxp3 is responsible for “scurfy” mice
- When overexpressed, Foxp3 leads to poor T cell proliferation and activation.