BDB565151
CD357 (GITR) Rat anti-Mouse, Alexa Fluor 647, Clone: DTA-1, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB565151-Each-of-1 | In Stock | ₹ 32,040.00 |
BDB565151 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 32,040.00
GST (18%): ₹ 5,767.20
Total Price: ₹ 37,807.20
Antigen
CD357
Classification
Monoclonal
Concentration
0.2mg/mL
Description
GITR; Gitr; glucocorticoid-induced TNFR-related protein; Tnfrsf18; AITR
Host Species
Rat
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Mouse
Isotype
IgG2b
Applications
Flow Cytometry
Clone
DTA-1
Conjugate
Alexa Fluor 647
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Mouse CD25+ CD4+ T Cell Line
Quantity
0.1 mg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Related Products
Description
- The DTA-1 monoclonal antibody specifically binds to GITR [Glucocorticoid-induced Tumor necrosis factor (TNF) receptor family-Related], a 66-70-kDa homodimer glycoprotein that is a member of the TNF receptor superfamily and is also known as TNFRSF18 and CD357
- As its name implies, GITR expression was first detected in T lymphocytes that had been treated with dexamethasone, a glucocorticoid
- In normal naive mice, GITR is expressed at moderate levels on CD25-positive/CD4-positive/CD8a-negative thymocytes and on CD25-positive/CD4-positive/CD45RB-low splenocytes
- It is also expressed at low levels on splenic CD25-negative/CD4-positive/CD45RB-low T lymphocytes, B lymphocytes, macrophages, and dendritic cells
- Activation of T and B lymphocytes upregulates GITR expression
- GITR is a costimulatory receptor that plays an important role in Regulatory T (Treg)-cell functions, and a GITR Ligand has been detected on B lymphocytes, macrophages, and dendritic cells
- mAb DTA-1 abrogates suppression by Treg cells without affecting their proliferative response, while it is co-stimulatory for T lymphocytes that are not Treg cells.