BDB565334
HLA-ABC Mouse, BUV395, Clone: G46-2.6, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB565334-Each-of-1 | In Stock | ₹ 32,885.50 |
BDB565334 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 32,885.50
GST (18%): ₹ 5,919.39
Total Price: ₹ 38,804.89
Antigen
HLA-ABC
Classification
Monoclonal
Conjugate
Brilliant Ultraviolet 395
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Baboon, Cynomolgus, Human, Rhesus Monkey
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
G46-2.6
Description
Major histocompatibility complex, class I, A,B,C; HLA class I A,B,C
Host Species
Mouse
Quantity
50 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- The Human Leukocyte Antigen (HLA) complex is the human version of the MHC, helping the immune system distinguish the body's own proteins versus those from foreign invaders, such as viruses
- Humans have three main MHC class I genes, known as HLA-A, HLA-B and HLA-C
- Major histocompatibility complex (MHC) class I molecules, which are widely found on the surface of nucleated cells, function by binding peptides and displaying them on the cell surface to cytotoxic T-cells
- Intracellular degradation of cytosolic proteins by the proteasome generates many of the peptides that load MHC class I molecules
- MHC class I may also serve as an inhibitory ligand for natural killer (NK) cell receptors (KIR, Killer Immunoglobulin-like Receptors), which viruses may modulate expression levels for to evade immune detection
- The G46-2.6 monoclonal antibody binds to a monomorphic epitope on the alpha chain of HLA-A, HLA-B and HLA-C
- The antibody was conjugated to BD Horizon BUV395 which has been exclusively developed by BD Biosciences as an optimal dye for use on a 355nm laser equipped instrument
- With an Ex Max at 348nm and an Em Max at 395nm, this dye has virtually no spillover into any other detector
- BD Horizon BUV395 can be excited with a 355nm laser and detected with a 379/28 filter.