BDB610624
ROCK-II Mouse, Unlabeled, Clone: 21, BD
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB610624-Each-of-1 | In Stock | ₹ 50,374.00 |
BDB610624 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,374.00
GST (18%): ₹ 9,067.32
Total Price: ₹ 59,441.32
Antigen
ROCK-II
Classification
Monoclonal
Concentration
250μg/mL
Description
ROKα
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
Applications
Western Blot
Clone
21
Conjugate
Unconjugated
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen
Rat ROKα aa. 567-718
Quantity
150 μg
Research Discipline
Cell Biology
Target Species
Canine, Human, Mouse, Rat
Isotype
IgG1
Related Products
Description
- Activity of the GTP-binding proteins is regulated by GAPs, that accelerate binding, and GTPases, that enhance the rate of GTP hydrolysis (Ras, Rho, cdc42Hs, and Rac)
- The isoforms of Rho, a small GTP-binding protein, regulate cellular processes such as the formation of the stress fibers, lamelipodia, and filopodia
- ROKα (RhoA-binding kinase) is a Ser/Thr protein kinase that interects with the GTP-binding form of RhoA
- Like RhoA, ROKα localizes at the cellular margins and colocalizes with acti filaments
- The ROKα gene encodes a protein of 1302 amino acids with homology to the human myotonic kinase
- Although ROKα binds to GTP-RhoA, it is not yet clear whether this interaction induces the kinase activity of ROKα
- Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting