BDB612801
CD11b Rat anti-Mouse, Brilliant Ultraviolet 737, Clone: M1/70, BD Horizon™
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB612801-Each-of-1 | In Stock | ₹ 21,004.00 |
BDB612801 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 21,004.00
GST (18%): ₹ 3,780.72
Total Price: ₹ 24,784.72
Antigen
CD11b
Classification
Monoclonal
Concentration
0.2mg/mL
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Mouse Splenic Cells
Quantity
25 μg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
M1/70
Conjugate
Brilliant Ultraviolet 737
Host Species
Rat
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Mouse
Isotype
IgG2b κ
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Description
- The M1/70 monoclonal antibody specifically binds to CD11b, also known as Integrin alpha M (Itgam or αM)
- CD11b is a 170-kDa type 1 transmembrane glycoprotein and belongs to the Integrin alpha chain family
- CD11b serves as the alpha chain of the heterodimeric Mac-1 integrin (CD11b/CD18, αMβ2), also known as complement receptor 3 (CR3)
- Mac-1 mediates adhesion to ICAM-1 (CD54), ICAM-2 (CD102), fibrinogen and binding to C3bi
- Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 B lymphocytes
- Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface
- The M1/70 antibody reportedly blocks cell adherence and C3bi binding but does not block cell-mediated lysis
- Cross-reaction of the M1/70 antibody with CD11b expressed on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported
- Due to spectral differences between labeled cells and beads, using BD™ CompBeads can result in incorrect spillover values when used with BD Horizon BUV737 reagents
- Therefore, the use of BD CompBeads or BD CompBeads Plus to determine spillover values for these reagents is not recommended
- Different BUV737 reagents (e.g., CD4 vs
- CD45) can have slightly different fluorescence spillover therefore, it may also be necessary to use clone specific compensation controls when using these reagents.