CD18 Monoclonal Antibody (TS1/18), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ENMA1810-Each-of-1 | In Stock | ₹ 46,146.50 |
ENMA1810 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,146.50
GST (18%): ₹ 8,306.37
Total Price: ₹ 54,452.87
Antigen
CD18
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
P05107
Gene Symbols
ITGB2
Immunogen
Human Beta 2 Integrin
Quantity
200 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry, Immunocytochemistry, Inhibition Assays
Clone
TS1/18
Conjugate
Unconjugated
Gene
ITGB2
Gene Alias
2E6; AI528527; antigen CD18; B-2 integrin; CD18; CD18 leukocyte adhesion molecule; CD18 subunit; cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor); cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; complement component 3 receptor 3 and 4 subunit; complement receptor C3 beta-subunit; complement receptor C3 subunit beta; integrin beta 2; integrin beta chain, beta 2; integrin beta-2; integrin subunit beta 2; integrin, beta 2; integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit); integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2); integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); ITGB2; LAD; LCAMB; Leu-CAM receptor; leukocyte cell adhesion molecule CD18; leukocyte surface protein; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; Lfa1; LFA-1; lymphocyte function associated antigen 1; MAC-1; Mac-1 beta; macrophage antigen 1 (mac-1) beta subunit); macrophage antigen-1 beta; MF17; MFI7
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
3689
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- MA1810 targets CD18 in FACS, IA, and ICC/IF applications and shows reactivity with Human samples
- This product has been tested for endotoxins by limulus amoebocyte lysate (LAL) assay and contains an endotoxin concentration of less than or equal to 10 endotoxin units per milligram (EU/mg)
- The MA1810 immunogen is human Beta 2 Integrin
- MA1810 detects CD18 which has a predicted molecular weight of approximately 83 kDa
- CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leucocytes
- CD18 can combine with integrin molecules CD11a-c to form heterodimers at the cell surface, and these heterodimers are known to participate in the process of cell adhesion as well as cell-surface mediated signaling
- CD18 forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18)
- In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits, and these integrins are essential for proper leukocyte migration, mediating intercellular contacts
- Absence of CD18 leads to leukocyte adhesion deficiency-1, severe reduction of CD18 expression leads to the development of a psoriasiform skin disease
- CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis
- Defects in the CD18 gene are the cause of leukocyte adhesion deficiency type I (LAD1)
- Two transcript variants encoding the CD18 protein have been identified.