CD11a Recombinant Rabbit Monoclonal Antibody (2B2), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA549985-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA549985 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
CD11a
Classification
Recombinant Monoclonal
Concentration
0.8 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
P20701
Gene Symbols
ITGAL
Immunogen
A synthesized peptide derived from human ITGAL
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Immunocytochemistry, Western Blot
Clone
2B2
Conjugate
Unconjugated
Gene
ITGAL
Gene Alias
(p180), alpha L integrin, antigen CD11A (p180), antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide, antigen CD11A p180, CD11 antigen-like family member A, CD11a, integrin alpha L, integrin alphaL, integrin alpha-L, integrin alpha-L precursor, integrin gene promoter, integrin subunit alpha L, integrin surface receptor, integrin, alpha L, integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide), ITGAL, Leukocyte adhesion glycoprotein LFA-1 alpha chain, leukocyte function-associated molecule 1 alpha chain, LFA-1, LFA-1 alpha, LFA1A, LFA-1A, Ly-15, Ly-21, lymphocyte antigen 15, lymphocyte function associated antigen 1, alpha polypeptide, lymphocyte function-associated antigen 1, lymphocyte function-associated antigen 1, alpha polypeptide, lymphocyte function-associated antigen-1
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3683
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG
Related Products
Description
- CD11a (LFA-1 alpha, ITGAL) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin
- CD11a is implicated in activation of LFA-1 complex
- CD11a plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling
- CD11a is expressed on the plasma membrane of leukocytes in a low-affinity conformation
- Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of CD11a to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3
- CD11a is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions
- Blocking of CD11a function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases
- For example, humanized anti- CD11a antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation, binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity
- Two transcript variants encoding different isoforms of CD11a have been found
- Diseases associated with CD11a dysfunction include benign cephalic histiocytosis and leukocyte adhesion deficiency.