Huntingtin Recombinant Rabbit Monoclonal Antibody (6F2), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA549884-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA549884 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
Huntingtin
Classification
Recombinant Monoclonal
Concentration
0.63 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
P42858
Gene Symbols
Htt
Immunogen
A synthesized peptide derived from human Huntingtin
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Immunohistochemistry (Paraffin)
Clone
6F2
Conjugate
Unconjugated
Gene
Htt
Gene Alias
AI256365, C430023I11Rik, Hd, HD protein, HD protein homolog, Hdh, HTT, Huntingtin, huntingtin (Huntington disease), Huntingtin, myristoylated N-terminal fragment, Huntington disease gene homolog, huntington disease protein, huntington disease protein homolog, IT15, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3064
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG
Related Products
Description
- Huntingtin is a disease gene linked to Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons
- This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product
- HD is a mid-life onset autosomal dominant neurodegenerative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years.The huntingtin locus is large, spanning 180 kb and consisting of 67 exons
- The huntingtin gene is widely expressed and is required for normal development
- It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues
- The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed
- The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein.