CXCR4 Recombinant Human Monoclonal Antibody (2D4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA549980-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA549980 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
CXCR4
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.03% Proclin 300, pH 7.4
Gene Accession No.
P61073
Gene Symbols
Cxcr4
Immunogen
Recombinant Human CXCR4 protein
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Neutralization
Clone
2D4
Conjugate
Unconjugated
Gene
Cxcr4
Gene Alias
b2b220Clo, C Cmotif chemokine, C X C motif chemokine, CC motif chemokine, CCmotif chemokine, CD antigen CD184, CD184, CD184 antigen, chemokine (C-X-C motif) receptor 4, chemokine (C-X-C) receptor 4, chemokine receptor, chemokine receptor (LCR1), chemokine receptor 4, chemokine receptor CXCR4, Cmkar4, CXC, CXC chemokine receptor, C-X-C chemokine receptor type 4, CXC motif chemokine, C-X-C motif chemokine receptor 4, CXCR4, CXC-R4, CXCR-4, D2S201E, FB22, Fusin, HM89, HSY3RR, HUMSTR, LAP3, LAP-3, LCR1, LESTR, Leukocyte-derived seven transmembrane domain receptor, leukocyte-expressed seven-transmembrane-domain, lipopolysaccharide-associated protein 3, LPS-associated protein 3, neuropeptide Y receptor Y3, neuropeptide Y3 receptor, NPY3R, NPYR, NPYRL, NPYY3R, PB-CKR, PBSF/SDF-1, pre-B-cell-derived chemokine receptor, SDF-1 receptor, Sdf1r, seven transmembrane helix receptor, seven-transmembrane-segment receptor, spleen, stromal cell-derived factor 1 receptor, WHIM, WHIMS
Host Species
Human
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
7852
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG4
Related Products
Description
- CXCR4 (Fusin, LESTR, HUMSTR) is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a co-receptor for X4 HIV-1 entry into CD4+ cells
- CXCR4 has been proved to be the co-receptor for HIV-2's binding to CD4 through envelope glycoprotein gp 120 and promotes Env-mediated fusion of the virus
- In other cases, CXCR4 can even function as the only receptor for HIV-2's binding to the CD4 host cells
- CXCR4 is the receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation
- CXCR4 acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels
- Also, CXCR4 is involved in hematopoiesis and in cardiac ventricular septum formation, and plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells
- In the CNS, CXCR4 could mediate hippocampal-neuron survival and is involved in cerebellar development
- CXCR4 binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes
- Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells
- The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites.