SOS1 Recombinant Rabbit Monoclonal Antibody (2B2), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550137-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA550137 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
SOS1
Classification
Recombinant Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
Q07889
Gene Symbols
SOS1
Immunogen
A synthesized peptide derived from Human SOS1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Flow Cytometry
Clone
2B2
Conjugate
Unconjugated
Gene
SOS1
Gene Alias
4430401P03Rik, 9630010N06, AI449023, G GINGF, GF1, GGF1, GINGF, gingival fibromatosis, gingival fibromatosis, hereditary, 1, guanine nucleotide exchange factor, guanine nucleotide releasing factor, HGF, NS4, ras guanine exchange factor, son of sevenless homolog 1, Son of sevenless homolog 1 (Drosophila), son-of-sevenless 1, SOS Ras/Rac guanine nucleotide exchange factor 1, SOS1, SOS-1
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
6654
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG
Related Products
Description
- Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation
- Sos1, and its closely related Sos2 paralog, are comprised of an N-terminal histone-binding domain, a RacGEF catalytic (DH) domain juxtaposed with a PH domain, a Ras exchanger motif (REM) domain, a RasGEF catalytic domain, and a C-terminal proline-rich region
- Sos1 catalyzes the GDP-GTP exchange within the membrane-bound GTPase Ras and thereby switches on a key signaling circuit that involves the activation of MAPK cascade central to cellular proliferation, survival and differentiation
- Growth factor stimulation rapidly induces the phosphorylation of Sos on multiple serine and threonine sites
- Phosphorylation of residues within the Sos C-terminus by the MAP/ERK kinase disrupts the Grb2-Sos complex.