FEMA550191
EGF Recombinant Rabbit Monoclonal Antibody (18B12), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550191-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA550191 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
EGF
Classification
Recombinant Monoclonal
Concentration
1.5 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
P01133
Gene Symbols
EGF
Immunogen
A synthesized peptide derived from Human EGF
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Flow Cytometry, Immunohistochemistry (Paraffin)
Clone
18B12
Conjugate
Unconjugated
Gene
EGF
Gene Alias
AI790464, beta-urogastrone, EGF, Epidermal growth factor, epidermal growth factor (beta-urogastrone), epidermal growth factor precursor, H-EGF, HOMG4, Pro-epidermal growth factor, Pro-epidermal growth factor precursor (EGF), sb:eu639, URG, Urogastrone
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1950
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG
Related Products
Description
- EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase
- Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family members
- Each dimeric receptor complex initiates a distinct signaling pathway by recruiting different Src homology 2 (SH2) containing effector proteins
- EGF is far and wide expressed in kidney, cerebrum, prostrate and salivary glands
- EGF acts as a potent mitogenic factor and the phosphorylated receptor recruits adapter proteins like GRB2 that activates complex downstream signaling cascades
- EGF activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STAT modules
- Research studies suggest the protein may also play important role in activating the NF-kappa-B signaling cascade
- Defects in the EGGF gene are the cause of hypomagnesemia type 4 and dysregulation has been associated with the growth and progression of certain cancers.