DDB2 Recombinant Rabbit Monoclonal Antibody (24E5), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550163-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA550163 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
DDB2
Classification
Recombinant Monoclonal
Concentration
0.4 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
Q92466
Gene Symbols
DDB2
Immunogen
A synthesized peptide derived from Human DDB2
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Clone
24E5
Conjugate
Unconjugated
Gene
DDB2
Gene Alias
2610043A19Rik, damage specific DNA binding protein 2, damage-specific DNA binding protein 2, 48kDa, damage-specific DNA-binding protein 2, DDB p48 subunit, DDB2, DDBb, DNA damage-binding protein 2, UV-damaged DNA-binding protein 2, UV-DDB 2, UV-DDB2, xeroderma pigmentosum group E protein, XPE
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1643
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG
Related Products
Description
- Damaged DNA binding protein (DDB) is a heterodimer composed of two subunits, p127 and p48, which are designated DDB1 and DDB2, respectively
- The DDB heterodimer is involved in repairing DNA damaged by μgtraviolet light
- Specifically, DDB, also designated UV-damaged DNA binding protein (UV-DDB), xeroderma pigmentosum group E binding factor (XPE-BF) and hepatitis B virus X-associated protein 1 (XAP-1), binds to damaged cyclobutane pyrimidine dimers (CPDs)
- Mutations in the DDB2 gene are implicated as causes of xeroderma pigmentosum group E, an autosomal recessive disease in which patients are defective in nucleotide excision DNA repair
- XPE is characterized by hypersensitivity of the skin to sunlight with a high frequency of skin cancer as well as neurologic abnormalities
- The hepatitis B virus (HBV) X protein interacts with DDB1, which may mediate HBx transactivation.