FEMA550208
Claudin 4 Recombinant Mouse Monoclonal Antibody (10F4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550208-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA550208 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
Claudin 4
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.03% Proclin 300, pH 7.4
Gene Accession No.
O14493
Gene Symbols
Cldn4
Immunogen
A synthesized peptide derived from Human CLDN4
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Flow Cytometry
Clone
10F4
Conjugate
Unconjugated
Gene
Cldn4
Gene Alias
Cep-r, claudin 4, CLAUDIN4, claudin-4, CLDN4, Clostridium perfringens enterotoxin receptor, Clostridium perfringens enterotoxin receptor 1, CPER, CPE-R, CPE-receptor, Cpetr, CPETR1, h CPE-receptor, hCPE-R, WBSCR8, Williams-Beuren syndrome chromosomal region 8 protein
Host Species
Mouse
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1364
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG
Related Products
Description
- Claudin-4 belongs to the 20-member family of claudins, transmembrane cellular adhesion proteins localized at epithelial and endothelial tight junctions
- Claudins demonstrate distinct, tissue-specific expression patterns, and are essential components of tight junction charge-specific channels that regulate paracellular ion flux
- Claudin-4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life
- The overexpression of Claudin-4 has been shown to decrease paracellular electrical conductance due to a selective decrease in Na+ permeability, with no significant decrease in Cl<sup>-</sup> permeability
- In ovarian carcinoma cells, Claudin-3 and Claudin-4 exhibit upregulation at both mRNA and protein levels
- Claudin-4 is also overexpressed in pancreatic cancer tissues and cell lines, and in other epithelial cancers
- The Claudin-4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.