CD204 Monoclonal Antibody (A8G2), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550610-Each-of-1 | In Stock | ₹ 41,741.00 |
FEMA550610 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,741.00
GST (18%): ₹ 7,513.38
Total Price: ₹ 49,254.38
Antigen
CD204
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
P21757
Gene Symbols
MSR1
Immunogen
Recombinant protein within Human CD204 aa 51-250/451.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
A8G2
Conjugate
Unconjugated
Gene
MSR1
Gene Alias
bovine scavenger receptor type II, CD204, Macrophage acetylated LDL receptor I and II, macrophage scavenger receptor 1, macrophage scavenger receptor type III, macrophage scavenger receptor types I and II, MRS-A, MSR, Msr1, MSR-A, phSR1, phSR2, RGD1564316, SCARA1, Scavenger receptor class A member 1, scavenger receptor class A, member 1, scavenger receptor type A, scavenger receptor type I, Scvr, SRA, SR-A, SR-AI, SR-AI/II, SR-AII
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
4481
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG1
Related Products
Description
- Positive control: THP-1 cell lysate treated with 80nM PMA for 72 hours, human liver tissue
- Predicted band size: 50 kDa Subcellular Location: Membrane
- CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene
- These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense
- The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs)
- The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms
- It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis
- The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages
- Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.