SATB2 Recombinant Rabbit Monoclonal Antibody (PD01-42), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550745-Each-of-1 | In Stock | ₹ 42,275.00 |
FEMA550745 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,275.00
GST (18%): ₹ 7,609.50
Total Price: ₹ 49,884.50
Antigen
SATB2
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
Q9UPW6
Gene Symbols
SATB2
Immunogen
Synthetic peptide within C terminal human SATB2 aa 680-733/733.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Immunohistochemistry (Paraffin)
Clone
PD01-42
Conjugate
Unconjugated
Gene
SATB2
Gene Alias
DNA-binding protein SATB2, FLJ21474, FLJ32076, GLSS, KIAA1034, KIAA1034-like DNA binding protein, MGC119474, MGC119477, mKIAA1034, RGD1562369, SATB family member 2, SATB homeobox 2, SATB2, special AT-rich sequence binding protein 2, special AT-rich sequence-binding protein 2, two cut domains-containing homeodomain protein
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
23314
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Related Products
Description
- Positive control: Human colon tissue, human colon carcinoma tissue, human appendix tissue
- Predicted band size: 82.5 kDa Subcellular Location: Nucleus
- DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold associated regions
- It is thought to recognize the sugar-phosphate structure of double-stranded DNA
- SATB2 is a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling
- It also acts as a docking site for several chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers
- SATB2 is required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes - probably by modulating BCL11B expression
- It is a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex
- Mutations in the gene are associate with cleft palate isolated (CPI).