MAVS Recombinant Rabbit Monoclonal Antibody (PSH0-30), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550801-Each-of-1 | In Stock | ₹ 39,338.00 |
FEMA550801 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,338.00
GST (18%): ₹ 7,080.84
Total Price: ₹ 46,418.84
Antigen
MAVS
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
Q66HG9, Q7Z434, Q8VCF0
Gene Symbols
MAVS
Immunogen
Synthetic peptide within human MAVS aa 2-50/540.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
PSH0-30
Conjugate
Unconjugated
Gene
MAVS
Gene Alias
CARD adapter inducing interferon beta, CARD adaptor inducing IFN-beta, Cardif, D430028G21Rik, IFN-B promoter stimulator 1, IFN-beta promoter stimulator-1, interferon beta promoter stimulator protein 1, interferon-beta promoter stimulator protein 1, IPS1, IPS-1, KIAA1271, MAVS, mitochondrial antiviral signaling protein, mitochondrial anti-viral signaling protein, mitochondrial antiviral-signaling protein, Putative NF-kappa-B-activating protein 031N, virus-induced signaling adapter, virus-induced signaling adaptor, virus-induced-signaling adapter, VISA
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
228607, 311430, 57506
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Related Products
Description
- Positive control: MCF7 cell lysate, C2C12 cell lysate, human colon tissue, human endometrium tissue, A431 cell
- Predicted band size: 56 kDa Subcellular Location: Membrane, Mitochondrion, Mitochondrion outer membrane, Peroxisome
- Two distinct signaling pathways activate the host innate immunity against viral infection
- One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response
- MAVS is a mitochondrial membrane protein that was identified as a critical component in the IFN beta signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B
- MAVS is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6
- MAVS also interacts with the IKK-alpha, IKK-beta and IKK-iota kinases through its C-terminal region
- Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system
- Multiple isoforms of MAVS are known to exist.