CD16b Monoclonal Antibody (8F1C10), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FERMA548455-Each-of-1 | In Stock | ₹ 43,565.50 |
FERMA548455 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,565.50
GST (18%): ₹ 7,841.79
Total Price: ₹ 51,407.29
Antigen
CD16b
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.05% sodium azide
Gene Accession No.
O75015
Gene Symbols
FCGR3B
Immunogen
Purified recombinant fragment of human CD16B (AA: 17-200) expressed in E. Coli.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot
Clone
8F1C10
Conjugate
Unconjugated
Gene
FCGR3B
Gene Alias
CD16; CD16B; Fc fragment of IgG receptor IIIb; Fc fragment of IgG, low affinity IIIb, receptor (CD16b); Fc gamma receptor IIIb; FCG3; Fc-gamma receptor IIIb (CD 16); Fc-gamma RIII; fc-gamma RIIIb; Fc-gamma RIII-beta; FCGR3; FCGR3B; FcR-10; FCRIII; FCRIIIb; IGFR3; IgG Fc receptor III-1; low affinity immunoglobulin gamma Fc region receptor III-B
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
2215
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG1
Related Products
Description
- CD16 (FCGR3A) is a 50-65 kDa cell surface molecule that exists in two forms - a transmembranous form expressed by NK cells and some T cells, and a phosphatidylinositol linked form expressed by granulocytes
- CD16 is a low affinity receptor for IgG (FcR III), and is an important receptor mediating ADCC by NK cells
- Human CD16 is expressed in two forms – FCGR3A and FCGR3B
- FCGR3A is associated with the FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity
- Mast cell FCGR3A is associated, with FcepsilonRI-beta subunit
- Besides IgG, FCGR3A can be triggered also by oligomeric IgE
- FCGR3B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a pro-adhesive phenotype
- Diseases associated with CD16 dysfunction include immunodeficiency 20 and systemic lupus erythematosus.