Rubicon Monoclonal Antibody (4F5B5), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FERMA548673-Each-of-1 | In Stock | ₹ 43,565.50 |
FERMA548673 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,565.50
GST (18%): ₹ 7,841.79
Total Price: ₹ 51,407.29
Antigen
Rubicon
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.05% sodium azide
Gene Accession No.
Q92622
Gene Symbols
RUBCN
Immunogen
Purified recombinant fragment of human RUBCN (AA: 859-972) expressed in E. Coli.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Western Blot
Clone
4F5B5
Conjugate
Unconjugated
Gene
RUBCN
Gene Alias
1700021K19Rik; 5330403K09; baron; Beclin-1 associated RUN domain containing protein; KIAA0226; mKIAA0226; RGD1305422; RIKEN cDNA 1700021K19 gene; RUBCN; Rubicon; RUN and cysteine rich domain containing beclin 1 interacting protein; RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein; run domain Beclin-1 interacting and cysteine-rich containing protein; run domain Beclin-1 interacting and cystein-rich containing protein; run domain Beclin-1-interacting and cysteine-rich domain-containing protein; RUN domain protein as Beclin 1-interacting and cysteine-rich containing; rundataxin; SCAR15; similar to mKIAA0226 protein
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
9711
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG1
Related Products
Description
- Two Beclin-1-interacting proteins, the run domain Beclin-1 interacting and cysteine-rich containing protein (Rubicon) and ATG14L, reciprocally regulate autophagy at different stages
- Knockdown of Rubicon caused enhancement of autophagy while that of ATG14L caused a defect in autophagosome formation
- Rubicon functions as part of a Beclin-1-PIK3C3-containing autophagy complex and is also an essential, positive regulator of the NAPDH oxidase complex
- Upon microbial infection or TLR2 activation, Rubicon interacts with the CYBA subunit of the NAPDH oxidase complex, leading to a burst of reactive oxygen species and inflammatory cytokines.