SHARPIN Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA540129-Each-of-1 | In Stock | ₹ 46,502.50 |
PA540129 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
SHARPIN
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SHARPIN
Gene Alias
0610041B22Rik; AW121341; Conneck1; cpdm; hSIPL1; mSIPL1; protein kinase C-interacting protein RBCC like 1; PSEC0216; RBCKL1; SHANK associated RH domain interactor; SHANK-associated RH domain interacting protein; SHANK-associated RH domain interactor; shank-associated RH domain-interacting protein; shank-interacting protein; shank-interacting protein-like 1; SHARPIN; SIPL1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
81858
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Concentration
3.41 mg/mL
Formulation
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.
Q9H0F6
Gene Symbols
SHARPIN
Immunogen
Recombinant protein encompassing a sequence within the center region of human SHARPIN.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: K562 and THP-1 cells
- Predicted reactivity: Chimpanzee (96%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation
- LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways
- Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation
- LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex
- Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.