SIGLEC8 Monoclonal Antibody (1A5B9), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FERMA548730-Each-of-1 | In Stock | ₹ 45,167.50 |
FERMA548730 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,167.50
GST (18%): ₹ 8,130.15
Total Price: ₹ 53,297.65
Antigen
SIGLEC8
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.05% sodium azide
Gene Accession No.
Q9NYZ4
Gene Symbols
SIGLEC8
Immunogen
Purified recombinant fragment of human SIGLEC8 (AA: extra 17-216) expressed in E. Coli.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Applications
ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Clone
1A5B9
Conjugate
Unconjugated
Gene
SIGLEC8
Gene Alias
CDw329; MGC59785; SAF2; SAF-2; sialic acid binding Ig like lectin 8; sialic acid binding Ig-like lectin 8; sialic acid-binding Ig-like lectin 8; Sialoadhesin family member 2; Siglec; SIGLEC8; Siglec-8; SIGLEC8L
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
27181, 292846
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG2b
Related Products
Description
- SIGLEC8 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells
- It preferentially binds to alpha2,3-linked sialic acid
- and also binds to alpha2,6-linked sialic acid
- The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface
- SIGLEC8 is expressed specifically on eosinophils
- The protein contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM)
- This motif is involved in downmodulation of cellular responses
- The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1
- The SIGLEC8 gene belongs to the immunoglobulin superfamily.