CD21/CD35 Monoclonal Antibody (7E9), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FERMA549032-Each-of-1 | In Stock | ₹ 45,879.50 |
FERMA549032 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,879.50
GST (18%): ₹ 8,258.31
Total Price: ₹ 54,137.81
Antigen
CD21/CD35
Classification
Monoclonal
Concentration
100 μg/mL
Formulation
PBS with 0.1% BSA and 0.02% sodium azide
Gene Accession No.
P19070
Gene Symbols
Cr2
Immunogen
Purified mouse CR1 from serum
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Form
Liquid
Applications
Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot
Clone
7E9
Conjugate
Unconjugated
Gene
Cr2
Gene Alias
C3b/C4b receptor; C3-binding protein; C3DR; CD21; CD35; CD35 antigen; Complement C3d receptor; complement component (3d/Epstein Barr virus) receptor 2; complement component 3d receptor 2; complement receptor 2; complement receptor type 1; complement receptor type 2; CR; Cr1; Cr-1; Cr2; Cr-2; CVID7; EBV receptor; Epstein-Barr virus receptor; expressed in B lymphocytes; SLEB9
Host Species
Rat
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
12902
Content And Storage
4° C
Isotype
IgG2a
Related Products
Description
- The monoclonal antibody 7E9 recognizes mouse complement receptors type 1 (CR1) and 2 (CR2)
- The monoclonal antibody 7E9 does not inhibit rosette formation between 2PK3 cells and Crd-coated SRBC indicator cells
- CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen
- CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens
- CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions
- A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands
- CD35 encodes a membrane glycoprotein found on peripheral blood cells, glomerular podocytes, and follicular dendritic cells
- The protein is a receptor for complement components C3b and C4b and regulates the activity of the complement cascade
- Variation in this protein is the basis of the Knops blood group system
- The two most common alleles, F and S, differ by 8 exons and are thought to be the result of an unequal crossover event
- A secreted form of the protein present in plasma has been described, but its full length nature has not been determined.