PrP Monoclonal Antibody (1.5D7), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FERMA549089-Each-of-1 | In Stock | ₹ 58,384.00 |
FERMA549089 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 58,384.00
GST (18%): ₹ 10,509.12
Total Price: ₹ 68,893.12
Antigen
PrP
Classification
Monoclonal
Concentration
100 μg/mL
Formulation
PBS with 0.1% BSA and 0.02% sodium azide
Gene Accession No.
P10279
Gene Symbols
PRNP
Immunogen
The monoclonal antibody 1.5D7 recognizes the disease associated isoform of the prion protein termed PrPSc
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Bovine
Form
Liquid
Applications
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Inhibition Assays, Western Blot
Clone
1.5D7
Conjugate
Unconjugated
Gene
PRNP
Gene Alias
AA960666; AI325101; Alternative prion protein; alternative prion protein; major prion protein; AltPrP; ASCR; BSE; CD230; CD230 antigen; CJD; GSS; KURU; major prion protein; major prion protein; alternative prion protein; major scrapie-associated fibril protein 1; MGC26679; p27-30; PK resistant core; prion protein; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); prion protein precursor; prion protein precursor PrP; prion protein PrP; prion protein variant a; prion protein variant b; prion protein, PrP; prion protein, structural; prion-related protein; PRIP; Prn; Prn-i; Prnp; Prn-p; PrP; PrP<C>; PrP27-30; PrP33-35C; PrPc; PrPSc; Sinc; SIP; TSE
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
281427
Content And Storage
4° C
Isotype
IgG2b
Related Products
Description
- Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule
- PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes
- Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD)
- Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.