PR3 Monoclonal Antibody (WGM2), FITC, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FERMA549095-Each-of-1 | In Stock | ₹ 80,011.00 |
FERMA549095 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 80,011.00
GST (18%): ₹ 14,401.98
Total Price: ₹ 94,412.98
Antigen
PR3
Classification
Monoclonal
Concentration
100 μg/mL
Formulation
PBS with 1% BSA and 0.02% sodium azide
Gene Accession No.
P24158
Gene Symbols
PRTN3
Immunogen
Monoclonal antibody WGM2 reacts with human proteinase 3 (PR3), a 30 kDa protein.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Flow Cytometry, Functional Assay, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Inhibition Assays, Western Blot
Clone
WGM2
Conjugate
FITC
Gene
PRTN3
Gene Alias
ACPA; AGP7; azurophil granule protein 7; CANCA; C-ANCA; C-ANCA antigen; leukocyte proteinase 3; MBN; MBT; mPR3; Myeloblastin; neutrophil proteinase 4; NP4; NP-4; P29; PR3; PR-3; Proteinase 3; PRTN3; serine proteinase, neutrophil; wegener autoantigen; Wegener granulomatosis autoantigen
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
5657
Content And Storage
4° C, store in dark
Isotype
IgG1
Related Products
Description
- Monoclonal antibody WGM2 blocks the PR3 activity and partially inhibits the binding of human PR3-ANCA to PR3
- Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246)
- By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369)
- May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279)
- [UniProt]