VISTA Recombinant Rabbit Monoclonal Antibody (PSH0-64), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FERMA549363-Each-of-1 | In Stock | ₹ 39,605.00 |
FERMA549363 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,605.00
GST (18%): ₹ 7,128.90
Total Price: ₹ 46,733.90
Antigen
VISTA
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
Q9H7M9
Gene Symbols
VSIR
Immunogen
Recombinant protein within human vista aa 1-194 / 311.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
PSH0-64
Conjugate
Unconjugated
Gene
VSIR
Gene Alias
4632428N05Rik, B7H5, B7-H5, C10orf54, C1H10orf54, C28H10orf54, C4H10orf54, chromosome 10 open reading frame 54, DD1alpha, Death Domain1alpha, Dies1, differentiation of ESCs 1, GI24, PD-1H, PDCD1 homolog, PD-H1, platelet receptor Gi24, PP2135, RIKEN cDNA 4632428N05 gene, SISP1, sisp-1, Stress-induced secreted protein-1, UNQ730/PRO1412, V-domain Ig suppressor of T cell activation, VISTA, V-set domain-containing immunoregulatory receptor, V-set immunoregulatory receptor, VSIR, V-type immunoglobulin domain-containing suppressor of T-cell activation
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
64115
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Related Products
Description
- Sequence Similarities: 95% Mouse/Rat
- Tissue Specificity: Expressed in spleen
- Detected on a number of myeloid cells including CD11b monocytes, CD66b-positive neutrophils, at low levels on CD4-positive and CD8-positive T-cells, and in a subset of NK cells
- Not detected on B cells (at protein level)
- Expressed at high levels in placenta, spleen, plasma blood leukocytes, and lung
- Expressed at moderate levels in lymph node, bone marrow, fat, uterus, and trachea
- Has low expression levels in other tissues
- Positive Control: Human brain tissue, human placenta tissue, human tonsil tissue, A375 cell lysate, HeLa cell lysate, human lung tissue lysate
- Subcellular Location: Cell membrane
- Predicted band size: 34 kDa
- VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene
- Although VISTA bears sequence homology to PD-L1 it has a different expression pattern
- In both mouse and humans, VISTA is expressed predominantly on hematopoietic cells with the highest densities on myeloid cells, and lower levels on T cells
- It is usually absent on B cells
- VISTA expressed by antigen presenting cells has been shown to directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a target for cancer immunotherapy
- The reported ligands of VISTA include CD28H, VSIG-3 and VSIG-8.