GPNMB Recombinant Rabbit Monoclonal Antibody (PSH0-82), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FERMA549360-Each-of-1 | In Stock | ₹ 39,605.00 |
FERMA549360 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,605.00
GST (18%): ₹ 7,128.90
Total Price: ₹ 46,733.90
Antigen
GPNMB
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
Q14956, Q6P7C7, Q99P91
Gene Symbols
GPNMB
Immunogen
Recombinant protein within human gpnmb aa 1-498 / 572.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
PSH0-82
Conjugate
Unconjugated
Gene
GPNMB
Gene Alias
Dchil, DC-HIL, dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand, dendritic cell-associated transmembrane protein, glycoprotein (transmembrane) nmb, glycoprotein nmb, glycoprotein nmb-like protein, glycoprotein nonmetastatic melanoma protein B, Gpnmb, hematopoietic growth factor inducible neurokinin-1, Hematopoietic growth factor inducible neurokinin-1 type, Hgfin, ipd, iris pigment dispersion, NMB, Osteoactivin, si:ch211-155k24.6, transmembrane glycoprotein HGFIN, transmembrane glycoprotein NMB, Unknown (protein for MGC:133733), UNQ1725/PRO9925
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
10457, 113955, 93695
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Related Products
Description
- Sequence Similarities: 98% Mouse/Rat
- Tissue Specificity: Widely expressed, but very low expression, if any, in the brain (PubMed:12609765, PubMed:16609006)
- Expressed in the epidermis with higher levels in melanocytes compared with keratinocytes and Langerhans cells (at protein level) (PubMed:29336782)
- Expressed in peripheral blood, but not bone marrow mononuclear cells (PubMed:12609765)
- Expressed in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level) (PubMed:16489096)
- May be overexpressed in various cancers, including melanoma and glioblastoma multiforme (PubMed:7814155, PubMed:16489096, PubMed:16609006)
- Positive Control: L929 cell lysate, A375 cell lysate, U-937 cell lysate, rat heart tissue lysate, B16F1 cell lysates, human lung tissue, L929
- Subcellular Location: Cell membrane, Melanosome membrane, Early endosome membrane
- Predicted band size: 64 kDa
- The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein
- GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines
- GPNMB may be involved in growth delay and reduction of metastatic potential
- Two transcript variants encoding different isoforms have been found for this gene.