E-cadherin Monoclonal Antibody (MB2), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA106300-Each-of-1 | In Stock | ₹ 47,481.50 |
MA106300 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
E-cadherin
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
P12830
Gene Symbols
CDH1
Immunogen
MCF-7/AZ cells expressing E-cadherin at their cell surface.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2b
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Clone
MB2
Conjugate
Unconjugated
Gene
CDH1
Gene Alias
AA960649; ARC-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-cadherin precursor; Epithelial cadherin; hab; half baked; LCAM; L-CAM; Um; UVO; Uvomorulin
Host Species
Mouse
Purification Method
purified
Regulatory Status
RUO
Gene ID (Entrez)
999
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- MA1-06300 detects E-cadherin in human samples
- MA1-06300 has sucessfully been used in Western blotting, Flow cytometry, immunocytochemistry on fixed cells (methanol fixation) and immunohistochemistry
- By Western blotting, it detects a ∽120 kDa protein representing E-cadherin
- The MA1-06300 immunogen is MCF-7/AZ cells expressing E-cadherin at their cell surface
- Store at 4oC, or in small aliquots at -20oC
- E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily
- The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail
- Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer
- Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis
- The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization
- Identified transcript variants arise from mutation at consensus splice sites
- E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity
- In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16
- Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.