RTN1 Monoclonal Antibody (RNL-3), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA106814-Each-of-1 | In Stock | ₹ 47,481.50 |
MA106814 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
RTN1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
Q16799
Gene Symbols
RTN1
Immunogen
Small cell lung cancer cell line NCI-H82.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Non-human Primate, Rabbit
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone
RNL-3
Conjugate
Unconjugated
Gene
RTN1
Gene Alias
0710005K15Rik; 4930441F12Rik; I79_024631; LOC100750648; MGC133250; MGC40985; Neuroendocrine-specific protein; Nsp; R75279; reticulon 1; reticulon-1; RP23-450G14.1; RTN1; Rtn1-a; Rtn1-b; Rtn1-c; S-rex
Host Species
Mouse
Purification Method
purified
Regulatory Status
RUO
Gene ID (Entrez)
100345452, 6252
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- MA1-06814 detects reticulon-1A(NSP-A) and reticulon-1B(NSP-B) in human, rabbit, and non-human primate cells
- MA1-06814 has sucessfully been used in Western blotting, immunocytochemistry, FACS and immunohistochemistry (paraffin) procedures
- By Western blot it detects a ∽135 kDa band representing reticulon-1A, and a ∽45 kDa band representing reticulon-1B
- The MA1-06814 immunogen is a small cell lung cancer cell line NCI-H82
- Reticulon-1 was formerly designated NSP for Neuroendocrine-Specific-Protein, because it is specifically expressed in neural and neuroendocrine tissues
- The NSP-gene has been mapped by fluorescence in situ hybridization to human chromosome 14q21-q22
- The NSP-gene encodes three overlapping proteins, i.e
- reticulon-1A (NSP-A), reticulon-1B (NSP-B), and reticulon-1C (NSP-C)
- These proteins were found to be anchored to membranes of the endoplasmic reticulum through their common carboxy-terminal regions
- Reticulon-1A is a protein with a molecular weight of approximately 135 kDa, which occurs in various isoforms presumably depending on the degree of phosphorylation of serine residues
- In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A
- Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82
- Reticulon-1B is so far not found in human tissues
- Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).