FceR1 alpha Monoclonal Antibody (CRA1 (AER37)), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA14997-Each-of-1 | In Stock | ₹ 61,588.00 |
MA14997 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 61,588.00
GST (18%): ₹ 11,085.84
Total Price: ₹ 72,673.84
Antigen
FceR1 alpha
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and no preservative; pH 7.4
Gene Accession No.
P12319
Gene Symbols
FCER1A
Immunogen
Region of FceR1 alpha (aa 26-197).
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Shrew
Product Type
Antibody
Isotype
IgG2b
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
CRA1 (AER37)
Conjugate
Unconjugated
Gene
FCER1A
Gene Alias
alpha polypeptide; fc epsilon r1; Fc epsilon receptor Ia; Fc epsilon RI alpha-chain; Fc fragment of IgE receptor Ia; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc IgE receptor, alpha polypeptide; Fc receptor, IgE, high affinity I, alpha polypeptide; Fce1a; Fc-epsilon RI-alpha; fcepsilonri; FCER1A; FcERI; Fcr-5; high affinity immunoglobulin epsilon receptor alpha-subunit; high affinity immunoglobulin epsilon receptor subunit alpha; IgE Fc receptor subunit alpha; Iger01; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; RATIGER01; RP11-550P17.3
Host Species
Mouse
Purification Method
purified
Regulatory Status
RUO
Gene ID (Entrez)
2205
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- MA1-4997 detects Fc epsilonR1 alpha from human samples
- The CRA1 (AER37) monoclonal antibody reacts with the Fc epsilonR1 alpha subunit on a region that does not overlap the region of the IgE binding site, thus it does not compete with IgE for the receptor bindings
- MA1-4997 has been successfully used in Western blot, immunocytochemistry, flow cytometry, and immunohistochemistry (paraffin, frozen) applications
- The MA1-4997 immunogen is region of Fc epsilonR1 alpha which does not overlap with the IgE binding site
- The epitope has been mapped to amino acids 26-110
- FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE
- Fc epsilonR1 alpha is a tetrameric complex consisting of one alpha, one β and two additional subunits
- The latter two are required for signal transduction activity
- The Fc epsilonR1 complex plays an important role in triggering allergic responses, and the immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response
- When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine, which are responsible for allergy symptoms, are released
- The IgE receptor couples allergen and mast cells to initiate the inflammatory responses that are characteristic of disorders such as hay fever and asthma
- The release of histamine and proteases leads to the synthesis of prostaglandins and leukotrienes-potent effectors of the hypersensitivity response.