FceR1 alpha Monoclonal Antibody (CRA2 (AER24)), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA14998-Each-of-1 | In Stock | ₹ 62,478.00 |
MA14998 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 62,478.00
GST (18%): ₹ 11,246.04
Total Price: ₹ 73,724.04
Antigen
FceR1 alpha
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and no preservative; pH 7.4
Gene Accession No.
P12319
Gene Symbols
FCER1A
Immunogen
Recombinant extracellular portion of recombinant human FcER1 alpha (corresponds to amino acids Met-26-197 excluding signal peptide 1-25).
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Applications
Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone
CRA2 (AER24)
Conjugate
Unconjugated
Gene
FCER1A
Gene Alias
alpha polypeptide; fc epsilon r1; Fc epsilon receptor Ia; Fc epsilon RI alpha-chain; Fc fragment of IgE receptor Ia; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc IgE receptor, alpha polypeptide; Fc receptor, IgE, high affinity I, alpha polypeptide; Fce1a; Fc-epsilon RI-alpha; fcepsilonri; FCER1A; FcERI; Fcr-5; high affinity immunoglobulin epsilon receptor alpha-subunit; high affinity immunoglobulin epsilon receptor subunit alpha; IgE Fc receptor subunit alpha; Iger01; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; RATIGER01; RP11-550P17.3
Host Species
Mouse
Purification Method
purified
Regulatory Status
RUO
Gene ID (Entrez)
2205
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- MA1-4998 detects Fc epsilonR1 alpha from human samples
- The CRA2 (AER24) monoclonal antibody reacts with the Fc epsilonR1 alpha subunit on a region that overlaps the region of the IgE binding site, thus it competes with IgE for the receptor binding
- Since MA1-4998 has been successfully used in Western blot, flow cytometry, and immunohistochemistry applications
- The MA1-4998 immunogen is region of Fc epsilonR1 alpha which overlaps with the IgE binding site
- The epitope has been mapped to amino acids 110-197
- FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE
- Fc epsilonR1 alpha is a tetrameric complex consisting of one alpha, one β and two additional subunits
- The latter two are required for signal transduction activity
- The Fc epsilonR1 complex plays an important role in triggering allergic responses, and the immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response
- When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine, which are responsible for allergy symptoms, are released
- The IgE receptor couples allergen and mast cells to initiate the inflammatory responses that are characteristic of disorders such as hay fever and asthma
- The release of histamine and proteases leads to the synthesis of prostaglandins and leukotrienes-potent effectors of the hypersensitivity response.