Complement C3b Monoclonal Antibody (6C9), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA170053-Each-of-1 | In Stock | ₹ 52,465.50 |
MA170053 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,465.50
GST (18%): ₹ 9,443.79
Total Price: ₹ 61,909.29
Antigen
Complement C3b
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
P01024, P01027
Gene Symbols
C3
Immunogen
Human C3.
Quantity
250 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG1
Applications
ELISA, Flow Cytometry
Clone
6C9
Conjugate
Unconjugated
Gene
C3
Gene Alias
Acylation stimulating protein; acylation-stimulating protein cleavage product; AHUS5; AI255234; ARMD9; ASP; C3; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3a; C3a anaphylatoxin; C3adesArg; C3b; C3bc; C3-beta-c; Complement C3; Complement C3 alpha chain; Complement C3 beta chain; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3c alpha' chain fragment 2; Complement C3d fragment; Complement C3dg fragment; Complement C3f fragment; Complement C3g fragment; complement component 3; complement component C3a; complement component C3b; CPAMD1; ENCF-1; ENCF-2; epididymis secretory sperm binding protein Li 62p; HEL-S-62p; HSE-MSF; iC3b; Neutrophil chemotactic factor-1; Neutrophil chemotactic factor-2; Plp; prepro-C3
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
12266, 718
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- MA1-70053 detects C3/C3b/iC3b in human and mouse samples
- MA1-70053 has been successfully used in flow cytometry and ELISA procedures
- The MA1-70053 immunogen is human C3
- Store at 4oC
- For long term storage, aliquot and freeze unused portion at -20oC in volumes appropriat for single usage
- Avoid freeze/thaw cycles
- Inactive complement component 3b (iC3b) is a 42kDa neoantigen present in blood serum
- Cleavage of C3b into iC3b by the protease factor I, in the presence of cofactors, changes the structure and resulting binding properties, preventing binding by complement factor B and properdin
- This prevents further progression of the complement pathway, providing another mechanism by which the complement pathway may be regulated
- iC3b is thought to play a role in inducing tolerance, binding complement receptor type 3 on antigen presenting cells and stimulating them to produce transforming growth factor beta2 and interleukin-10
- It is thought to stimulate B-cells via the CD21 receptor providing a link between the innate and adaptive immune responses
- Additionally iC3b acts as an opsonin which is recognised by complement receptor 3 expressed on leukocytes or complement receptor of the immunoglobulin superfamily (CRIg) on Kupffer cells, stimulating phagocytosis of the tagged cells
- iC3b levels are often elevated in diseases such as Systemic Lupus Erythematosis and Rheumatoid arthritis.