IGF1R alpha Monoclonal Antibody (1H7), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA181739-Each-of-1 | In Stock | ₹ 70,532.50 |
MA181739 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 70,532.50
GST (18%): ₹ 12,695.85
Total Price: ₹ 83,228.35
Antigen
IGF1R alpha
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative; pH 7.4
Gene Accession No.
P08069
Gene Symbols
Igf1r
Immunogen
Proprietary Immunogen.
Quantity
500 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin), Western Blot
Clone
1H7
Conjugate
Unconjugated
Gene
Igf1r
Gene Alias
A330103N21Rik; CD221; D930020L01; hyft; IGF-1 receptor; Igf1r; IGF-1R; IGF-I receptor; IGFIR; IGFIRC; IGFR; Igfr1; insulin like growth factor 1 receptor; insulin-like growth factor 1 receptor; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; insulin-like growth factor 1 receptor beta subunit; insulin-like growth factor I receptor; insulin-like growth factor receptor 1; insulin-like growth factor-I receptor; insulin-like growth factor-I receptor precursor; JTK13; line 186; soluble IGF1R variant 1; soluble IGF1R variant 2
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
3480
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- Clone 1H7 recognizes an epitope in the alpha subunits of CD221, demonstrated by Western blotting, and is reported to partically block binding of IGF-I and IGF-II to CD221
- This product requires protein digestion pre-treatment of paraffin sections using trypsin or pronase
- A suggested positive control for immunohistochemical applications is pancreas or placenta
- For FACS analysis, use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL
- This product is a low-endotoxin, preservative-free formulation
- Endotoxin level is <0.01 EU/ug
- IGF1R (Insulin-like Growth Factor1 Receptor) is a receptor tyrosine kinase that mediates actions of insulin-like growth factor 1 (IFG1)
- It binds IGF1 with high affinity and IGF2/insulin with lower affinity
- Activated IGF1R is involved in cell growth and survival control
- IGF1R is crucial for tumor transformation and survial of malignant cells
- Ligand binding activates the receptor kinase and leads to receptor autophosphorylation and tyrosines phosphorylation of multiple substrates that function as signaling adapter proteins.