IGF1R (CD221) Monoclonal Antibody (1B1), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FERMA549051-Each-of-1 | In Stock | ₹ 56,248.00 |
FERMA549051 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 56,248.00
GST (18%): ₹ 10,124.64
Total Price: ₹ 66,372.64
Antigen
IGF1R (CD221)
Classification
Monoclonal
Concentration
100 μg/mL
Formulation
PBS with 0.1% BSA and 0.02% sodium azide
Gene Accession No.
P08069
Gene Symbols
IGF1R
Immunogen
Recombinant IGF-1R (aa 1-932)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Flow Cytometry, Immunocytochemistry, Inhibition Assays
Clone
1B1
Conjugate
Unconjugated
Gene
IGF1R
Gene Alias
A330103N21Rik; CD221; CD221 antigen; D930020L01; hyft; IGF 1 receptor; IGF 1R; IGF1R; IGF-1R; IGF-I receptor; IGFIR; IGFIRC; IGFR; Igfr1; insulin like growth factor 1 receptor; Insulin like growth factor 1 receptor precursor; insulin-like growth factor 1 receptor; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; Insulin-like growth factor I receptor; JTK13; line 186; soluble IGF1R variant 1; soluble IGF1R variant 2
Host Species
Rat
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
3480
Content And Storage
4° C
Isotype
IgG2b
Related Products
Description
- Antibody 1B1 recognizes the extracellular domain if IGF-1R
- IGF1R, also known as Insulin-like Growth Factor 1 (IGF-1) Receptor, is a receptor tyrosine kinase activated by IGF-1 and IGF-2
- IGFR has been implicated in a variety of cancers
- The protein is a tetramer consisting of two alpha, and two beta subunits
- The alpha-subunits binds to insulin growth factor 1 with higher affinity than to insulin growth factor 2
- Binding results in a conformational change, followed by autophosphorylation of IGF-1R at positions 1134, 1135, 1136
- The activated IGF-1R in turn, causes phosphorylation of substrate proteins, followed by sequential activation of RAS, RAF, and mitogen-activated protein kinase isoforms ERK, p38, and JNK, leading to the transcription of genes that drive proliferation.