Tn Antigen Monoclonal Antibody (Tn 218), Invitrogen™

Description

• MA1-90544 stains Tn antigen in epithelial carcinoma, pancreatic, colon, stomach and breast
• A suggested positive control for this product is human gastrointestinal tumor
• The antibody is supplied as concentrated tissue culture supernatant in PBS with 0.05% azide
• Aberrant glycosylation is a hallmark of cancer cells
• The blood group precursors T (Thomsen-Friedenreich) and Tn epitopes are shielded in healthy and benign-diseased tissues but uncovered in approximately 90% of carcinomas
• T and Tn glycoproteins are specific, autoimmunogenic pancarcinoma antigens
• These antigens may also be found in neoplastic blood cells
• Fundamental, chemical and physical aspects of these glycoproteins of primary carcinomas are discussed first
• Tn and T epitopes are cell and tissue adhesion molecules, essential in invasion by and metastasis of carcinoma which includes adherent and proliferative phases
• Immunohistochemical studies of the extent of Tn antigen expression in primamry breast carcinoma demonstrate its highly significant correlation with clinical pathological tumor stages, and hence its value as a reliable prognisticator.