CaV1.1 Monoclonal Antibody (1A), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA3920-Each-of-1 | In Stock | ₹ 46,235.50 |
MA3920 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,235.50
GST (18%): ₹ 8,322.39
Total Price: ₹ 54,557.89
Antigen
CaV1.1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.05% sodium azide; pH 7.4
Gene Accession No.
P07293, Q02485, Q02789, Q13698
Gene Symbols
CACNA1S
Immunogen
Purified rabbit muscle T-tubule dihydropyridine receptor.
Quantity
200 μL
Primary or Secondary
Primary
Target Species
Guinea Pig, Human, Mouse, Rabbit, Rat
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
1A
Conjugate
Unconjugated
Gene
CACNA1S
Gene Alias
AW493108; CACH1; Cacn1; Cacna1s; Cacnl1a3; calcium channel, L type, alpha 1 polypeptide, isoform 3 (skeletal muscle, hypokalemic periodic paralysis); calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; calcium channel, voltage-dependent, L type, alpha 1S subunit; calcium voltage-gated channel subunit alpha1 S; Cav1.1; Cav1.1 alpha-1; CCHL1A3; DHP; DHPR; DHPR alpha1s; dihydropyridine calcium channel receptor protein; dihydropyridine receptor; dihydropyridine receptor alpha 1 subunit; dihydropyridine receptor alpha 1S; dihydropyridine receptor alpha-1S subunit; dihydropyridine-sensitive L-type calcium channel alpha-1 subunit; fmd; HOKPP; HOKPP1; hypoPP; mdg; MHS5; muscle dysgenesis; ROB1; sj; TTPP1; unnamed protein product; voltage-dependent L-type calcium channel subunit alpha-1S; Voltage-gated calcium channel subunit alpha Cav1.1
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
100009585, 100734741, 12292, 682930, 779
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- MA3-920 detects 1,4-dihydropyridine (DHP) receptor alpha-1 subunit in human, rat, mouse, guinea pig and rabbit skeletal muscle
- The DHP Receptor alpha-1 protein is also known as CACNA1S or Cav1.1 alpha-1 subunit
- MA3-920 has been successfully used in Western blot, FACS, immunohistochemistry and immunoprecipitation procedures
- By Western blot, this antibody detects an ∽200 kDa protein representing the DHP receptor in rat skeletal muscle extracts
- Immunohistochemical staining of DHP receptor in rabbit skeletal muscle with MA3-920 results in double rows of discrete punctate staining representing pairs of triads on the opposing sides of the Z-lines
- This product can be used to inhibit the DHP-sensitive calcium current in BC3H1 mouse muscle cells
- The MA3-920 antigen is purified rabbit muscle T-tubule DHP receptor
- Voltage-sensitive calcium channels mediate the entry of calcium into many types of excitable cells and thus play a key role in neurotransmitter release and excitation-contraction (E-C) coupling
- The 1,4-dihydropyridines (DHPs) are synthetic organic compounds which can be used to identify the L-type calcium channels that are found in all types of vertebrate muscle, neuronal and neuroendocrine cells
- The DHP receptor is part of the L-type calcium channel complex and is thought to be the voltage sensor in E-C coupling
- The purified DHP receptor isolated from triads is composed of at least four subunits
- The alpha-1 subunit contains the binding site for the DHPs and shows high sequence homology to the voltage gated sodium channel
- The alpha-2 subunit is a large glycoprotein associated with the DHP receptor which was first described in skeletal muscle and is also found in high concentrations in other excitable tissues such as cardiac muscle and brain and in low concentrations in most other tissues studied
- The other two subunits that co-purify with the DHP receptor are termed beta and gamma.