MilliporeSigma™ Sorting Nexin-17, Mouse, Unlabeled, Clone: 4B8.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABC1211MI-Each-of-1 | In Stock | ₹ 42,968.31 |
MABC1211MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,968.31
GST (18%): ₹ 7,734.296
Total Price: ₹ 50,702.606
Antigen
Sorting Nexin-17
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q15036
Immunogen
GST-tagged recombinant fragment from the FERM-like region of human Sorting Nexin-17.
Quantity
100 μg
Research Discipline
Apoptosis & Cancer
Gene ID (Entrez)
NP_001253989
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
4B8.1
Conjugate
Unconjugated
Gene
SNX17, KIAA0064
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 4B8.1 recognizes an internal epitope within the FERM-like region present in both spliced isoforms of human sorting nexin-17 reported by UniProt (Q15036).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2b κ
Related Products
Description
- Sorting nexin-17 (UniProt Q15036) is encoded by the SNX17 (also known as KIAA0064) gene (Gene ID 9784) in human
- The sorting nexins (SNXs) constitute a family of adaptor proteins involved in proteins trafficking through the endosomal pathway
- Originally identified as a binding partner of the cell adhesion protein P-selectin, sorting nexin-17 (SNX17) has since been shown to mediate internalization and recycling of multiple cell surface proteins including P-selectin, amyloid precursor protein (APP), integrin β1, low density lipoprotein receptor (LDLR), LDLR related protein (Lrp1), ApoER2, and FEEL1
- All SNX proteins contain a conserved phox homology (PX) domain that mediates phosphoinositides binding in a SNX type-specific manner, as well as various scaffolding modules including SH3, BAR, and PDZ domains
- SNX17 PX domain (a.a
- 1-109) displays specificity for phosphatidylinositol 3-monophosphate, which is enriched at the cytoplasmic face of the early endosome
- SNX17 also contains a 4.1 protein/ezrin/radixin/moesin (FERM) domain (a.a
- 115-432) comprised of an ubiquitin/Ras association (RA) subdomain known as the F1 lobe (a.a
- 113-205), an F2 lobe (a.a
- 206-269) with a helical structure similar to acyl-CoA binding protein, and an F3 lobe (a.a
- 270-388) similar to the phosphotyrosine binding (PTB)/pleckstrin homology domain
- The FERM domain mediates interaction with Asn-Pro-Xaa-Tyr/Phe (NPX(Y/F) motif-containing proteins for internalization as well as interaction with adaptor proteins-containing PTB (or FERM) domains to trigger signaling events.