MilliporeSigma™ E3 Ubiquitin Ligase BRE1B, Mouse, Unlabeled, Clone: 4H8.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE949MI-Each-of-1 | In Stock | ₹ 41,813.98 |
MABE949MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,813.98
GST (18%): ₹ 7,526.516
Total Price: ₹ 49,340.496
Antigen
E3 Ubiquitin Ligase BRE1B
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
O75150
Immunogen
GST-tagged recombinant internal fragment from the C-terminal half of human BRE1B .
Quantity
100 μL
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_001193962
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
4H8.1
Conjugate
Unconjugated
Gene
RNF40, BRE1B, KIAA0661
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 4H8.1 epitope region is present in all three spliced isoforms of human BRE1B reported by UniProt (O75150).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- E3 ubiquitin-protein ligase BRE1B (UniProt O75150; also known as 95kDa retinoblastoma-associated protein, BRE1-B, RBP95, RING finger protein 40, Syntaxin-1-interacting RING finger protein, Protein staring) is encoded by the RNF40 (also known as BRE1B, KIAA0661) gene (Gene ID 9810) in human
- Proteini ubiquitination is mediated by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s)
- There exist RING finger-type (really interesting new gene), HECT-type (homologous to E6-AP C-terminus), and U-box type of E3 ligases
- RING finger ubiquitin ligase members can function as monomers, dimers, or multi-subunit complexes
- The RNF20-RNF40 heterodimer mediates the ubiquitination of histone H2B at Lysine 120, an event that plays an important role in decompacting chromatin fiber to allow transcription elongation, in stem cell differentiation, as well as in DNA double-strand breaks (DSBs) repair via the homologous recombination (HR) and nonhomologous end-joining (NHEJ) pathways
- Human RNF40 is a 1001-amino acid protein containing a RING-type zinc finger in its C-terminal region (a.a
- 948-987) that mediates its interaction with RNF20.