MABC572MI
MilliporeSigma™ anti-c-Ret Clone: 6F3.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABC572MI-Each-of-1 | In Stock | ₹ 50,816.33 |
MABC572MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,816.33
GST (18%): ₹ 9,146.939
Total Price: ₹ 59,963.269
Antigen
c-Ret
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
P07949
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Expected to react with both the RET51 and the RET9 isoforms, as well as the extracellular cell-membrane anchored RET cadherin 120kDa fragment (a.a. 29-707).
Content And Storage
2°C to 8°C for one year from date of shipment
Isotype
IgG1 κ
Applications
Western Blot
Clone
6F3.1
Formulation
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
RET, CDHF12, CDHR16, PTC, RET51
Immunogen
GST-tagged recombinant protein corresponding to the extracellular domain of human c-Ret.
Quantity
100 μg
Research Discipline
Apoptosis, Cancer
Gene ID (Entrez)
NP_066124
Target Species
Rat
Form
Purified
Related Products
Description
- Specifically detects c-Ret Clone: 6F3.1 in Rat samples, and it is validated for Western Blotting Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1; UniProt P07949; also known as Cadherin family member 12, Cadherin-related family member 16, Hydroxyaryl-protein kinase, Proto-oncogene c-Ret, Rearranged during transfection, Receptor tyrosine kinase, Ret proto-oncogene, RET receptor tyrosine kinase, RET transforming sequence) is encoded by the RET (also known as CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51) gene (Gene ID 5979) in human
- Ret is a receptor tyrosine kinase that mediates the activation of several signaling pathways including the PLC gamma, Ras, JNK and inositol phosphate pathways
- Ret mutations have been shown to be causative in several diseases, including Hirschsprung's disease (HD), papillary thyroid carcinoma, multiple endocrine neoplasia (MEN) 2A, MEN 2B, and familial medullary thyroid carcinoma
- Ret is initially produced with a signal peptide sequence (a.a
- 1-28), the removal of which yields the mature Ret (a.a
- 20-1114)
- Ret can be posttranslationally cleaved into the extracellular cell-membrane-anchored RET cadherin 120kDa fragment (a.a
- 29-707) and the soluble RET kinase fragment (a.a
- 708-1017).