MABC582MI
MilliporeSigma™ Mouse anti-hIAP-1/BIRC3, Clone: 11D12.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABC582MI-Each-of-1 | In Stock | ₹ 42,968.31 |
MABC582MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,968.31
GST (18%): ₹ 7,734.296
Total Price: ₹ 50,702.606
Antigen
hIAP-1/BIRC3
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
BIRC3; API2; IAP1; MIHC; RNF49
Immunogen
GST-tagged recombinant protein corresponding to the BIR 1/2 of human hIAP-1/BIRC3.
Quantity
100 μg
Research Discipline
Apoptosis, Cancer
Gene ID (Entrez)
NP_001156
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1 κ
Applications
Western Blot
Clone
11D12.1
Gene Accession No.
Q13489
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
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Description
- Specifically detects hIAP-1/BIRC3 clone: 11D12.1 in Human samples, and it is validated for Western Blotting Baculoviral IAP repeat-containing protein 3 (UniProt Q13489; also known as API2, Apoptosis inhibitor 2, Baculoviral IAP repeat-containing 3, c-IAP2, hIAP-1, hIAP1, IAP homolog C, IAP-1, Inhibitor of apoptosis protein 1, Mammalian IAP homolog C, RING finger protein 49, TNFR2-TRAF-signaling complex protein 1) is encoded by the BIRC3 (also known as API2, AIP1, IAP1, HAIP1, HIAP1, MALT2, MIHC, RNF49) gene (Gene ID 330) in human
- hIAP-1 (c-IAP2) belongs to the inhibitor of apoptosis (IAP) family of proteins characterized by the presence of at least one baculoviral IAP repeat (BIR) domain
- hIAP-1 (c-IAP2 contains three BIR (BIR1/2/3) domains, followed by an UBA (ubiquitin-associated), a CARD (caspase activation and recruitment domain), and a RING (really interesting new gene) domain
- The BIR domains mediate hIAP-1 interaction with various binding partners, such as caspases, other IAP family members, and receptor-associated complexes
- The RING domain and its associated E3 ligase mediates not only the ubiqutination of substrate proteins, such as caspase-3, caspase-7, SMAC/DIABLO, but also self-ubiquitylation
- The UBA domain enables hIAP-1 to engage protein complexes containing poly-ubiquitylated protein(s).