MABF1452MI
MilliporeSigma™ anti-TCR beta chain, APC, Clone: H57-597,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF1452MI-Each-of-1 | In Stock | ₹ 15,842.00 |
MABF1452MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 15,842.00
GST (18%): ₹ 2,851.56
Total Price: ₹ 18,693.56
Antigen
TCR beta chain
Classification
Monoclonal
Conjugate
APC
Gene Accession No.
P0C6B2
Host Species
Armenian Hamster
Purification Method
Purified by size-exclusion chromatography
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
2°C to 8°C for one year from date of shipment protected from light; Do not freeze
Isotype
IgG
Applications
Flow Cytometry
Clone
H57-597
Formulation
Purified Armenian Hamster monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols
Ptcra, pT-alpha-TCR
Immunogen
Proprietary immunogen
Quantity
25 μg
Research Discipline
Inflammation, Immunology
Target Species
Mouse
Form
Purified
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Description
- Specifically detects TCR beta chain Clone: H57-597 in Mouse samples, and it is validated for Flow Cytometry The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR)
- This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells
- A small number of T cells may express an alternative heteromer of gamma and delta protein chains, known as the gamma-delta TCR
- These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells
- Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death
- The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR
- It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis
- The antibody does not cross-react with cells expressing the gamma-delta TCR.