MABF1502MI
MilliporeSigma™ anti-CD11c Red Fluor 710, Clone: N418,
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF1502MI-Each-of-1 | In Stock | ₹ 30,133.62 |
MABF1502MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 30,133.62
GST (18%): ₹ 5,424.052
Total Price: ₹ 35,557.672
Antigen
CD11c
Classification
Monoclonal
Conjugate
Red Fluor 710
Gene Accession No.
Q9QXH4
Host Species
Armenian Hamster
Purification Method
Purified by size-exclusion chromatography
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Isotype
IgG
Applications
Flow Cytometry
Clone
N418
Formulation
Purified Armenian Hamster monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols
Itgax
Immunogen
Proprietary immunogen
Quantity
100 μg
Research Discipline
Inflammation, Immunology
Target Species
Mouse
Form
Purified
Related Products
Description
- Specifically detects CD11c Clone: N418 in Mouse samples, and it is validated for Flow Cytometry The N418 antibody reacts with mouse CD11c, also known as integrin alpha X
- This 150kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g
- fibrinogen (cell-matrix)
- In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation
- Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed
- Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor complex known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The N418 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type
- CD11c is prominently expressed on tissue macrophages, and is also detected on some types of activated T cells and intestinal intraepithelial lymphocytes (IEL).