Siglec-H, Rat anti-Mouse, Clone: 551, Millipore Sigma™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF2045100-Each-of-1 | In Stock | ₹ 42,969.20 |
MABF2045100 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,969.20
GST (18%): ₹ 7,734.456
Total Price: ₹ 50,703.656
Antigen
Siglec-H
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified rat monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
Siglech;Siglec-H
Immunogen
Bone marrow-derived Type 1 interferon-producing cells.
Quantity
100 μg
Research Discipline
Inflammation & Immunology
Gene ID (Entrez)
NP_848821.2
Target Species
Mouse
Form
Purified
Applications
Flow Cytometry, Immunohistochemistry
Clone
551
Dilution
Immunohistochemistry Analysis: A representative lot detected Siglec-H in Immunohistochemistry applications (Yun, T.J., et. al. (2016). Cell Metab. 23(5):852-66).Flow Cytometry Analysis: A representative lot detected Siglec-H in Flow Cytometry applications (Yun, T.J., et. al. (2016). Cell Metab. 23(5):852-66).
Gene Alias
Sialic acid binding Ig-like lectin H;Siglech
Host Species
Rat
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 551 is a rat monoclonal antibody that detects murine Siglec-H. It targets an epitope with in the extracellular domain.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Anti-Siglec-H, clone 551, Cat
- No
- MABF2045, is a rat monoclonal antibody that detects Sialic acid binding Ig-like lectin H and has been tested for use in Flow Cytometry and Immunohistochemistry
- Siglec-H (UniProt: Q3Y597; also known as Sialic acid binding Ig-like lectin H) is encoded by the Siglech gene (Gene ID: 233274) in murine species
- Siglecs are sialic acid-binding immunoglobulin-like lectins that are expressed mostly in the immune system and may be involved in both adhesive and signaling functions
- Siglec-H is a type I, CD33-related siglec-like transmembrane glycoprotein that is synthesized with a signal peptide (aa 1-18), which is subsequently cleaved off in the mature form
- The mature form has to ig-like domains (aa 32-141 and 151-234) in its extracellular region
- Unlike other CD33-related siglecs, it lacks tyrosine-based signaling motifs in its cytoplasmic tail
- Siglec-H is shown to be expressed on plasmaocytoid dendritic cells (pDCs) and can serve as a reliable marker for these cells
- Siglec-H is also reported to serve as an endocytic receptor expressed on murine pDCs
- Action of Siglec-H depends on a 12 kDa DNAX-activating protein (DAP)
- (Ref.: Zhang, J., et al
- (2006)
- Blood 107(9); 3600-3608; Yun, TJ., et al., (2016), Cell Metabolism 23(5); 852-866).