MilliporeSigma™ Mouse anti-LAG3, Clone: 8C7.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF294MI-Each-of-1 | In Stock | ₹ 36,371.63 |
MABF294MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 36,371.63
GST (18%): ₹ 6,546.893
Total Price: ₹ 42,918.523
Antigen
LAG3
Classification
Monoclonal
Formulation
Mouse monoclonal IgG2aκ antibody tissue culture supernatant with 0.05% sodium azide.
Gene Symbols
LAG3; FDC
Immunogen
Mouse Fc-tagged recombinant human LAG3 extracellular fragment.
Quantity
100 μL
Research Discipline
Inflammation and Immunology
Gene ID (Entrez)
NP_002277
Content And Storage
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Isotype
IgG2a κ
Applications
Flow Cytometry, Western Blot
Clone
8C7.1
Gene Accession No.
P18627
Host Species
Mouse
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Supernatant
Related Products
Description
- Specifically detects LAG3 clone: 8C7.1 in Human samples, and it is validated for Flow Cytometry, Western Blotting Lymphocyte activation gene 3 protein (UniProt P18627; also known as CD223, LAG-3, Protein FDC) is encoded by the LAG3 (also known as FDC) gene (Gene ID 3902) in human
- LAG3 is a single-pass type I membrane protein that binds MHC class II molecules on antigen presenting cells with high affinity
- LAG3 expression is induced after T cell activation and functions as a negative regulator of T cell function
- LAG3 blockage is shown to augment T cell proliferation and cytokine production, and LAG3-deficient mice have a defect in the downregulation of T cell responses induced by staphylococcal enterotoxin B or by virus infection
- In addition, LAG3 is expressed on activated regulatory T (Treg) cells at higher levels than on activated effector T cells
- LAG3 blockage inhibits the suppressive activity of Treg cells
- LAG3 is also upregulated on tumour-infiltrating lymphocytes (TILs), and LAG3 blockage can enhance anti-tumour T cell responses.