MilliporeSigma™ Mouse anti-EBI3 (Neutralizing), Clone: V1.4H6.25,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF836MI-Each-of-1 | In Stock | ₹ 44,393.20 |
MABF836MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,393.20
GST (18%): ₹ 7,990.776
Total Price: ₹ 52,383.976
Antigen
EBI3 (Neutralizing)
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG3κ in buffer containing PBS without preservatives.
Gene Symbols
Ebi3; Il27b
Immunogen
Recombinant protein corresponding to mouse EBI3/IL-35.
Quantity
100 μg
Research Discipline
Inflammation and Immunology
Gene ID (Entrez)
NP_056581
Content And Storage
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Isotype
IgG3 κ
Applications
Neutralization, Western Blot
Clone
V1.4H6.25
Gene Accession No.
O35228
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Mouse
Form
Purified
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Description
- Specifically detects EBI3 (Neutralizing) clone: V1.4H6.25 in Mouse samples, and it is validated for Neutralization, Western Blotting EBI3/IL27B is the beta subunit of the functional cytokine IL-27
- The beta subunit is required for activity
- IL-27 is a critical cytokine of mammalian innate immune response
- IL-27 has both pro and anti-inflammatory activities
- IL-27 regulates T-helper cell development and differentiation into TH1, TH2 and TH17 effector cells
- IL-27 also is important in isotype switching for B-cells, and it drives rapid clonal expansion of native but not memory CD4 cells
- IL-27 is also important for its anti-tumor and anti-angiogenic activity on tumor and cancer cells
- The beta subunit EBI3/IL27B is also a component of IL-35 which is a heterodimer of IL-12alpha and IL-27B/EBI3
- IL-35 plays a role in immune suppression
- IL-27 is a secreted cytokine, thus IL-27beta subunit is expressed intracellularly associated with the endoplasmic reticulum and membrane vesicles and is detected extracellularly as part of the mature cytokine as well.